Three of the four managers leading their teams out at Wembley for this weekend's FA Cup semi-finals will do so knowing defeat could have serious ramifications for their short-term future.
Aston Villa were relegated from the Premier League for the first time since it began in 1992 when they suffered their 24th loss of the season in a 1-0 defeat at Old Trafford on Saturday.
News of all that transpired on and off the football field
The Wives and girlfriends of the England stars playing in cash-rich Premier League have rocked England shirts with their other-half's name on.
Leicester's EPL title credentials on show against champions Chelsea.
Manchester United and Manchester City must switch their focus from the Champions League to the Premier League when they meet at Old Trafford on Sunday in a derby that Louis van Gaal says will show whether United are true title contenders.
England defender John Stones has been ruled out of their final two Euro 2016 qualifiers through injury, the FA said in a statement.
Liverpool flirted with what would have been an embarrassing low in their poor start to the season as they were taken to penalties by fourth tier Carlisle United, but came through to reach the League Cup fourth round on Wednesday.
India's One-day International cricket team captain Mahendra Singh Dhoni is among Forbes magazine's 100 highest-paid athletes in the world.
After Sunday's crushing 4-2 derby defeat at Manchester United, even a top four finish and a place in next season's Champions League is no longer a certainty.
Manchester United maintained their push for a Champions League place after a Juan Mata goal on Saturday pushed Norwich City to the brink of relegation.
If anyone is living proof that the drugs don't work, it is Dwain Chambers.
Paul Pogba repaid some of his world record transfer fee with two goals as Manchester United rediscovered their early-season shine, cruising to a 4-1 Europa League win over Fenerbahce to go top of their group on Thursday. Pogba scored a penalty and rifled United's third into the top corner. Anthony Martial also netted from the spot and Jesse Lingard fired home in the second half before former Old Trafford favourite Robin van Persie pulled one back for Fenerbahce. Inter Milan and AS Roma, though, had more testing evenings. Coach Frank de Boer breathed a sigh of relief when Inter survived an onslaught from Southampton to end a three-match losing streak with a 1-0 victory while Roma conceded twice late on to draw 3-3 at home to Austria Vienna.
Manchester City set a new top-flight record of 15 consecutive wins as their seemingly unstoppable march towards the English Premier League title continued with a 4-0 romp at bottom club Swansea City.
Manchester United were denied by a spirited Stoke City performance as Joe Allen pounced late to secure the visitors their first point at Old Trafford since 1989 in a deserved 1-1 Premier League draw.
Chelsea overpowered West Ham United and Manchester City outclassed West Bromwich Albion as the Premier League title rivals signalled their intent at the start of a hectic holiday programme on Friday.
Daley Blind's late second half strike helped a lacklustre Manchester United salvage a 2-2 draw against West Bromwich Albion at The Hawthorns in the Premier League on Monday.
Zlatan Ibrahimovic is poised to write the final chapter in a glittering career with Manchester United in England's Premier League and although drama is guaranteed, a happy ending is not.
Tottenham Hotspur brutally exposed Liverpool's defensive frailties as Harry Kane plundered two more goals in his side's 4-1 romp at Wembley on Sunday.
Villa's chief executive Christian Purslow said 10 first-team players are among 14 positive cases of coronavirus at the club.
Teenager Marcus Rashford followed up two goals on his Manchester United debut in midweek with another double plus an assist as Louis van Gaal's team dented Arsenal's Premier League title hopes with a 3-2 win on Sunday.
Gareth Southgate's plea for England to play with adventure and style was answered only fitfully as his reign as caretaker manager began with a 2-0 win over Malta in a World Cup Group F qualifier on Saturday.
It is their best finish for 54 years, since the glory days of the 1960s when the club was setting new standards in English football under Bill Nicholson.
Match-by-match facts and statistics ahead of the Premier League
Images from the football matches played across Europe on Tuesday.
The dynasty will only be built on European success, though, and after the quarter-final exit to Liverpool, Manchester City's owners, who want a gilded continental powerhouse to match United's global lustre, will demand it and back those demands with huge funding.
Leicester go five clear after win at Everton
Jamie Vardy equalled the English Premier League record by scoring for a 10th successive match as his Leicester City side went top after winning 3-0 at Newcastle United while champions Chelsea ended their slump with a 1-0 win over Norwich City on Saturday.
IMAGES from the English Premier League matches played on Saturday
Manchester United's Zlatan Ibrahimovic proved his hunger for silverware has not diminished with age as the Swede's double earned a 3-2 win over Southampton in an absorbing League Cup final at Wembley.
Manchester United took over at the top of the Premier League while Barcelona's Argentine forward Lionel Messi could be out for up to two months with a knee injury and rampant Bayern Munich extended their perfect start to seven league wins.
Swansea City came from behind to end Manchester United's unbeaten start to the Premier League season with an impressive 2-1 victory at the Liberty Stadium on Sunday.
Another unconvincing display from Manchester United was compounded by a needless red card for Angel Di Maria.
Tottenham Hotspur striker Harry Kane was named player of the month after scoring six goals in four league games.
Despite all the hype, however, the match will do well to live up to some of the Manchester derby tussles down the years. Here are five of the most memorable:
Charlie Adam scored twice as Stoke City beat Manchester United 2-1 on Saturday to show the flailing Premier League champions it will take more than one big-money signing to improve their fortunes.
Manchester United ushered in a new era under interim manager Ryan Giggs with a 4-0 Premier League win over Norwich City on Saturday full of the verve and attacking intent often absent under the sacked David Moyes.
Jose Mourinho shared the honours with former mentor Louis van Gaal as his Chelsea side drew at Manchester United in the Premier league on Sunday, but there was no doubt which of the pair was happier with the 1-1 result.
A plethora of high-profile attacking signings had expectant Manchester United fans dreaming of a return to the upper echelons of European football, but their failure to identify their defensive problems is threatening to derail those hopes.
Jamie Vardy sent a screaming reminder that leaders Leicester City are in the Premier league title race for the long haul with a sensational strike in a 2-0 win over Liverpool on Tuesday.
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